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That would be a Lamarckian answer
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Our focus in this work is on conformational ensembles accessible to proteins under strongly denaturing conditions
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Recently, Zhou (114) computed the functional form of x^sup 2^P(x) from EV simulations of proteins studied by Wilkins et al
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However, quenching experiments and proteolysis patterns suggest conformational changes in the presence of PEP; furthermore, the thermal stability of EI^sup SC^ was modified depending on the effector added
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On the contrary, an important consequence of creating an internal cavity of 40 in I7S and 100 [Angstrom]^sup 3^ in F110S, presumably filled with water (18,19), is the onset of large amplitude structural fluctuations that increase remarkably the flexibility of the globular fold, as evidenced by the three to four orders of magnitude increase in permeability to acrylamide (18)
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We repeated this study in the absence of membranes using freshly dialyzed CPM-PLCβ-Gβγ and found that in solution the volume change increases to 78 ± 3 ml/mol
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Effect of high pressure on the association of melittin to membranes
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