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We then "flip a two-sided coin" to decide if the trial move is going to be a backbone or side-chain move
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The key to solving the protein-folding problem lies in an accurate description of the denatured state
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5-5 mM for I7S, and 1
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Given that early stage X
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Hydrodynamic calculations on the CaM:SMLCK complex showed that its diffusion tensor is nearly axially symmetric with a (τ^sup o^^sub m^)^sub app^ pattern for the α-helices that is almost a mirror image of that in the CaM:SEF2-1mp complex, Fig
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Simple versions of these models have indeed been able to account rather well for folding rates as a function of secondary structure formation (Myers and Oas, 1999, 2001)
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It is also possible that "kinetic traps" arise not just from low-energy intermediate states, but from intermediate diffusive subspaces of higher dimension than two, for which the control of dimensionality has been incomplete
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In contrast to the compact CD4, gp120 undergoes a number of significant loop contractions and translocations upon CD4 binding, which occur on a more extended timescale than the high-frequency local fluctuations
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The cooperativity coefficients (n) are all close to unity: 1
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"For Janice Alston, the uninsured nurse's assistant, the barriers to medication aren't about public health advantages or macroeconomic efficiency; they're about a lack of control over her medical care, and a system, purportedly in her interest, that places barriers between her and lifesaving medication
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75# 74#Note: period-specific average monthly rates relativeto rates in the pre-RP period indicated with #
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Tracking Prescription Drug AbuseWilson Compton, MD, heads NIDA's Division of Epidemiology, Services and Prevention Research
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On the other hand, four-fifths of the survey respondents said that ads encourage patients to seek unnecessary treatments and don't fully convey the therapies' risks
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But wahtever the next act in the crisis, don't be fooled by the assertion that the problem is Iran's pursuit of nuclear arms
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- The real issue is not whether Medicare received 1,000 claims, but rather, how many of those claims got into their system
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. ANS binding studies ANS (1-anilino-8-naphthalene sulfonate) binding experiments were executed with both the native and recombinant protein
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. As will be discussed below, we expect our results to be valid for the strict limit of maximally denatured proteins
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. If the move is accepted, we set U = U', return to step 2, and iterate until convergence
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. 2 can at best provide a rough indication of the thermodynamic parameters governing ANS binding
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.The author is very grateful to Yuanjian Guo, Finly Philip, and Louisa Dowal for supplying many of the reagents
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. In practice, of course, the dimensionality of the folding space is enormous
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. The configurational entropy analysis in terms of combined trajectories presented here shall potentially provide accurate estimations of thermodynamic properties of biomolecules given sufficient sampling of conformational space
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. The RNA strands were deprolected, purified by denaturing urea gel elcctrophoresis, desalted and subsequently purified by reversed-phase high-performance liquid chromatography utilizing an eluent system of acetonitrile and aqueous triethylammonium acetate (100 mM, pH 7)
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.--Pharmaceutical Sciences Pharmaceutical Health and Outcomes Sciences* SOUTH DAKOTASouth Dakota State University College of Pharmacy M
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. Boston, The Health Institute, New England Medical Center
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