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Structural rearrangements then take place at the dimer interface (and presumably also in other domains of each subunit), leading to a final, compact dimer structure
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When biology textbooks describe the mechanism Lamarck proposed for evolution, they unfailingly invoke his explanation of neck length in giraffes: Giraffes have long necks, Lamarck maintained, because their forebears were continually stretching to reach the highest leaves in trees
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Of the numerous roles credited to glycosylation the major ones are to facilitate proper folding, prevent protein aggregation, protect against proteolytic attack, and act as surface cell receptors and targeting signals (4,5)
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For PPA, which already exposes tryptophan residues to the protein surface in the folded state, a blue shift of the emission spectrum occurs upon thermal unfolding (see Fig
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When comparing ThT and DCVJ fluorescence data from a protofibrillar sample of TTR (24 h incubation), it is evident that DCVJ shows pHindependent fluorescence (Fig
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The approach to generate these species in solution opens up the possibility to probe the process by a wide number of biochemical and biophysical techniques to provide insight into the mechanism of protein misfolding and misassembly
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Total length (TL), body length (=standard length), head length (HL), predorsal length (PDL), and preanal length (PAL) were measured to the nearest 1 mm
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The free energy of binding, however, is small due to a remarkable entropy/enthalpy compensation
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Those recruitment efforts apparently now have been delayed for at least several months, and several dozen applicants already certified now must go through the testing process again, according to the NABP
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Medicaid funding cuts add to pharmacy's woesJames FrederickA crisis in funding for state Medicaid programs has washed through the chain and independent drug store industries this year like a tidal surge, further eroding the already weakened financial pillars that keep community pharmacy above water
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- " The Legend is a four-CD set of 104 selections, 7 previously unreleased
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. The obtained peak maxima around 336-338 nm indicate rather small red shifts (~2-3 nm) with respect to the native state (see also Fitter and Haber-Pohlmeier (14))
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. Such a correlation diagram of R^sub ex^ and ΔR^sub ex^ is shown in Fig
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.Time-resolved fluorescenceTime-resolved measurements of tryptophan (Trp) fluorescence were recorded using an IBH (Glasgow, UK) 5000 U fluorescence lifetime spectrometer system with 1 nm resolved excitation and emission monochromators (5000 M)
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