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Source: Georgia Tech College of Management's Financial Analysis Lab
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. Although the glycosylated form undergoes a simple two-state unfolding, the nonglycosylated species unfolds via a compact monomeric intermediate that is not a molten globule
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. , glycans attached to subunit X forming hydrogen bonds with residues of subunit X), whereas the rest are intersubunit interactions
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. Thermodynamic and folding properties versus structure among the members of a protein family Early studies suggested that folding and equilibrium pathways of homologous proteins were similar, and that the folding of a certain structure was thus conserved through evolution (58,59)
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. Second, while PSR knockout mice (from three different groups) all displayed developmental defects and die perinatally, (29-31) one of these did not exhibit defects in apoptotic cell clearance
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. To aid comparing the ANS binding propensity among the various proteins Table 2 lists the minimum number of binding sites (n) as well as the ratio n/Mw, normalization by the molecular weight taking into account that larger macromolecules, such as oligomers, have a greater probability to bind ANS simply for their larger mass
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. Strambini Consiglio Nazionale delle Ricerche, Istituto di Biofisica, 56124 Pisa, Italy Submitted September 22, 2005, and accepted for publication January 9, 2006
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. 6, whereas Table 1 collects the data for residues with significant exchange broadening (see table legend for more details)
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. Whereas the results at pH 5
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. 02-30 Hz, a viscous liquid-like response
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. These enzymes deplete the polar HDL surface of the proteins or phospholipids and/or increase the apolar lipid core, thereby creating a mismatch between the particle surface and its core (clay et al
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. One of the most potent research tools used for studying the structure of amyloids is atomic force microscopy (AFM)
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. The structure of the ternary complex of the core of gp120, CD4, and a CD4-induced antibody is the only available atomic information to date (Kwong et al
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. After eliminating the denaturing force the proteins are not able to fold back into their native (and functional) structure and the still unfolded proteins form (or just stay on with) aggregates
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. 9 (the root mean square (rms) error in ΔH^sup #^ is ~4 kcal/mol, based on the rms error in f of ~0
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. Backbone dynamics of calmodulin studied by N-15 relaxation using inverse detected 2-dimensional NMR-spectroscopy: the central helix is flexible
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.Time-resolved fluorescenceTime-resolved measurements of tryptophan (Trp) fluorescence were recorded using an IBH (Glasgow, UK) 5000 U fluorescence lifetime spectrometer system with 1 nm resolved excitation and emission monochromators (5000 M)
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