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. Protein concentration used for isothermal melts in lhe fluorimeler was 0
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. It is on the basis of this invariance to "spatial dilatations" (39) that polymers in the EV limit are said to he rcnormalizable entities
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. At first glance, these results are surprising since the highly denatured state is the starting point for in vitro folding reactions and yet no consideration of the denatured-state topology is required to account for the folding rates
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. Using these procedures, the energetics and pathways of folding, as well as the existence of transient intermediate states between unfolded and fully folded polypeptides, have been characterized for a number of proteins (for a collection of reviews, see Creighton, 1992; Pain, 1994)
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