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The sequence of the events was characterized by analyzing the signs of the peaks in the 2D IR correlation plots using rules proposed by Noda (29)
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9, which plots the probabilities, P^sub oa^(r = U), of finding cavities of different sizes at the ensemble-averaged center-of-mass as a function of cavity radius a
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This inherent weakness of the Flory mean-field theory also demands extreme caution when extrapolating simulation or experimental results from peptides (10,12,43,58,101,102,129,138) to draw conclusions about denatured proteins
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Upon dimer formation, the higher pail of the groove, formed by the helix-loop-heiix motif and the rest of the protein (and which traps Tip^sup 461^, was partly fixed by the other monomer via several salt bridges, thus bumpering solvent-accessibility to the indole moiety
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6 K), all the measurements are within experimental error, and the differences are probably due to the broadness of the transition
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For all studies the following buffer was used: 30 mM Mops, 50 mM NaCl, 2 mM CaCl^sub 2^, pH 7
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A promising approach to elucidate the effect of aggregation in more detail and maybe on a quantitative level would be the use of encapsulation techniques
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Study of the "molten globule" intermediate state in protein folding by a hydrophobic fluorescent probe
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Consequently, MR spectra obtained with sufficient SNR from the nucleus can be expected to reflect both the transport into the nucleus and the DNA binding of the drug
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The date acquisition card settings were chosen to give a time resolution 10-100 ps depending on the decay time of the fluorescent probe in question
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Our suggestion is that a discriminating design of key nonnative interactions may significantly speed the search for the native state
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Relative head length remained constant, whereas relative head depth diminished during development (Fig
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Hsu,* Christine Peter,[dagger] Wilfred F
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Such a procedure takes into account the shot noise-induced broadening of the peak (Deniz et al
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For decades consumer advocacy organizations have warned the public to be wary of new prescription drugs because information about their safety is dangerously incomplete
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In a recent scandal involving the Dallas Police Department, 24 Mexican immigrants were convicted on drug charges after police informants planted bags of ground-up billiard chalk on them
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regulators are concerned about assigning pharmaceutical safety liability to pharmacists who fall outside their jurisdiction or protecting American consumers from medicines that are free from any government oversight
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