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. * In Seattle, the terra-cotta domed roof of First United Methodist Church will soon make way for a highrise office tower
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. and 32 European countries were asked if the following statement was true or false: "Human beings, as we know them, developed from earlier species of animals
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. There is evidence that blind people develop above-average abilities in specific tasks related to hearing or to touching
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. ACYI is, to some extent, a thermostable enzyme with an optimal temperature for activity at ~65°C
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. making the monomermonomer interaction less stable
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. In contrast all thermal unfolded states (with the exception of those obtained from PPA) exhibit λ^sub max^ values around 340 nm, which correspond to much smaller red shifts upon unfolding
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. Dynamics of Proteins and Nucleic Acids
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. Osmotic stress and nonequilibrium phase diagramIn Figs
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. In FAP, mutants of TTR misfold and form amyloid deposits in peripheral nerves, causing peripheral neuropathy
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. The +4°C shift, the reduced height, and the increased width (decreased cooperativity) of this peak as compared to the sharp transition in DMPC vesicles at 24°C (Chapman, 1975) are characteristic of lipoprotein disks that have smaller co-operative lipid domains than vesicles
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. 33 K/min is sigmoidal and reaches a plateau at high temperatures, suggesting that the unfolding transition is complete at 99°C, yet the light-scattering curve recorded in the same experiment does not reach a plateau, and the signal continues to increase upon cooling from 99°C (Fig
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. , enable protofilaments to form fibrils (Jimenez et al
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. The model also shows that high-dimensional structures provide conceptual relations between different models of protein folding
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. BerkeleyDepartment of Fisheries and WildlifeHatfield Marine Science Center2030 SE Marine Science DriveOregon State UniversityNewport, Oregon 97365Present address (for S
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. We define this reference time as the average burst duration within the 0
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. In this collection of 11 articles, contributors describe their work in PTKs in such areas as using PTKs as targets for cancer and other indications, targeting Src homology 2 domains in drug discovery, using P12-kinase inhibition as a target for therapeutic intervention, using an activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia and JAK kinases in leukemia, lymphomas and multiple myeloma, applying platelet-derived growth factor, using a targeted therapy for myelogenous leukemia, testing signal transduction inhibitors in animal models of cancer, and using phosphoproteomics in drug discovery and development
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. Internal correlations show scale invariance As noted in the introduction, the self-repelling nature of proteins in the EV limit imposes correlations on all length scales
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. we plot ln([left angle bracket]R^sub ij^[right angle bracket]) versus ln(|j - i|) for four representative sequences drawn from Table 1
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