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. The data support the presence of at least two intermediate states in the equilibrium unfolding of GR by GdnHCl
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. The peptide unit is always trails with ω = 179
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. Interestingly, similar results are obtained for the protein modeled as a fully extended conformation (Fig
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. The loss of entropy stemming from the rigidification of the residues in gp120 forming stable hydrophobic contacts to CD4-F43 (ΔS^sup 2nd,b-f^^sub gp120,F43cav^ = -0
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. Entropy calculations on a reversibly folding peptide: changes in solute free energy cannot explain folding behavior
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. It is generally accepted from thermodynamic and biochemical data that the β-sheet of gp120 that bridges the inner and outer domain of the gp120 core, the bridging sheet, is only fully formed and stabilized upon complexation with CD4 (Fig
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