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. it is tempting to suggest that the sole peak observed in the thermal scans of EI^sup sc^ was due to the EIN^sup sc^
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. 2]-glycoprotein-I, protein S, and annexin I
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. 5 b, but was also observed for all other α-amylases which otherwise exhibit aggregation upon thermal unfolding
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. Thanks to an unusually blue shifted Trp fluorescence spectrum of native azurin, a measure of the protein fraction remaining native after freezing-thawing can be obtained directly from the residual fluorescence intensity at 300 nm (λ^sub ex^ = 292 nm), a wavelength where denatured-aggregated proteins were found to contribute little to the overall intensity
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. Upon Ca^sup 2+^ binding, a conformational change enables it to interact with over 100 different target proteins, including transcription factors (for reviews, see Van Eldik and Watterson and others (6,7))
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. In conclusion, the relaxation data show that the dimeric CaM:SEF2-1mp complex has an additional nanosecond-timescale internal motion (~2
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. In the extreme, protein instability produces serum separation in the package and/or a meltdown that is curdy and shows whey separation
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.ChEs provide a particularly suitable system for studying relationships between activity, ligand binding, unfolding, and thermal molecular fluctuations due to the following properties:1
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. The peptide still interacts with the same exposed hydrophobic patches as in the wraparound binding mode, but here a number of weak interactions occur instead of one strong
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. Similar CD and turbidity data of apoC-1:DMPC disks were reported earlier (Gursky et al
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. Simple versions of these models have indeed been able to account rather well for folding rates as a function of secondary structure formation (Myers and Oas, 1999, 2001)
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. We remark that in both these cases, the stabilized hypergutter provides an arena in which "diffusion-collision" calculations can operate within a molten globule, so constituting a significant generalization of that model to nonspatial degrees of freedom (Zhou and Karplus, 1999)
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.RESULTSConfigurational entropy of gp120 and CD4The configurational entropy of various sets of atoms of the free gp120 and CD4 molecules and their complex are shown in Figs
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