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. In the final structure, the interface domain is hidden in a hydrophobic, packed core surrounded by the other domains, as demonstrated by crystallographic studies of human GR (Schulz et al
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. These data suggest that the percentages of helical structure in EI^sup sc^ at the extremes of pH were increased
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. the dimeric surface was losing hydrogen bonds (which yielded ΔΔG = + 5
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. which contrasts with the monoexponential unfolding kinetics of apoC-1:DMPC and apoA-1:DMPC disks, may possibly relate to the dimeric nature of human apoA-2
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. Furthermore, the evolutionary tailoring of nonnative interactions provides additional "design-space" within which a pathway to the folded state may be coded, but without compromising the stability of the final, native state
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. 001 NSAIDs 95%CIEffect of Type 1 RPCumulative effect over all months -$10,900,000-$4,098,872Cumulative effect per year -$1,505,318-$565,362Effect of Type 2 RPCumulative effect over all months -$24,800,000 -$20,600,000Cumulative effect per year -$4,378,332-$3,636,312Table 5: Effect of RP on Patient NSAID ExpendituresNSAIDs Estimate p-ValueEffect of Type 1 RPCumulative effect over all months $666,340
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. The Johns Hopkins team decided to combine the therapies, predicting that the protein would penetrate the liposomes and make them deliver their load of drug more efficiently
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. For all three fluxes shown in Fig
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.Relaxation functions in folding kineticsWe first take a very simple case: if the nonnative gutter-stabilizing interactions are perfectly balanced with the entropy changes at each stage of the dimension reduction, then the free-energy profile is itself flat, and the d diffusive dimensions form an effective one-dimensional path along which the folding takes place
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