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. Since the diffusion is always maintained in some low-dimensional subspace of the full folding space, τ ~ R^sup 2^/D for each subspace, so that τ^sub fold^ ≈ d^sup 2^R^sup 2^/D rather than the exponentially larger (R^sup 2^/R^sup 2^^sub N^)^sup d^
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. For example, Fourier transform infrared spectroscopy experiments when conducted on freeze labile proteins have not detected significant changes in their secondary structure (2) presumably because they are carried out at relatively large protein concentrations, a condition in which the perturbation is often attenuated as if the protein itself acted as a stabilizer
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. ΔR^sub ex^ via either set of equations is essentially the same in the fast exchange region
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.5-ns internal motion in the CaM:SEF2-1mp complex can be attributed to motions of the separate N- and C-terminal domains of CaM, because the free domains have an overall correlation time of ~3 ns
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.As described in the Theory section, k^sub ex^ can be derived from the correlation between R^sub ex^ and ΔR^sub ex^ without prior assumption on the timescale of the exchange
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. At subsaturation levels of membranes, Gβγ dissociates above 1000 atm, which may be due to the phase transition, but at higher lipid concentrations, CPM-Gβγ membrane association is stable throughout the pressure range (Fig
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.5-bisphosphate and the α and βγ subunits of G-proteins
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