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. " To convey an idea of just how obsessed Raines had become, and how he passed on that obsession to his top managers, the OFHEO report quotes at some length from a speech given in 2000 by Sampath Rajappa, head of the Office of Auditing, to his accounting team: By now every one of you must have 6
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. Since K^sub SV^ equals the product of the bimolecular quenching rate constant (k^sub q^) and the excited-state lifetime of the fluorophore ([tau]), the value of K^sub SV^ obtained from steady-state fluorescence measurements is dependent on the average lifetime
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. 5 M GdnHCl caused only a minor decrease in ellipticity at 222 nm (Fig
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. The wetting reactions and intermetallic formations were also investigated through the microstructures of solder/Cu and solder/Ni interfaces to determine the wetting and bonding conditions
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. Additional dehydration of monocations can occur inside DNA grooves as a result of deformation of DNA secondary structure
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. Structure of the B-DNA cationic shell as revealed by an x-ray diffraction study of CsDNA
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. Such work is ongoing in our laboratories, and data from misfolded TTR oligomers recorded from site-specific fluorescence labeling of cysteine mutants have provided size distributions with average rotation correlation times of ~ 150 ns (K
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. This is of course a restatement of Levinthal's paradox (Levinthal, 1969; Karplus, 1997), but a helpful one, in that the two necessary assumptions for the paradox to arise are clearly seen
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. 5 percent of total prescriptions, 56 percent of new prescriptions and 12 percent of dollar sales for the first six months of 2004
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.CONCLUSIONSA series of incoherent elastic neutron scattering experiments were carried out on native and soman-inhibited human butyrylcholinesterase, as well as on Drosophila melanogaster acetylcholinesterase, to investigate the influence of irreversible chemical modifications (active-site phosphorylation) and structural differences (glycosylation, oligomeric state) on protein molecular dynamics
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. Harmonic behavior of trehalose-coated carbon-monoxy-myoglobin at high temperature
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. Although the blank fluorescence for DCVJ is low, DCVJ in the presence of unfolded TTR shows even lower fluorescence than the blank, which could indicate a small quenching effect through binding
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.Literature CitedAigner, P
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