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. Assuming an average lifetime of 3 ns for Trp in aqueous solution (Ferreira, 1989), the resulting value of K^sub SV^ for iodide quenching of Trp is 19
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. The precipitate was removed by centrifugation at 8000 rpm for 30 min
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. Partial motivation for this reference line comes from the work of Zagrovic and Pande (78), who showed that internal distances in unfolded ensembles of several proteins follow the predictions of the ideal random-flight chain with link length of 3
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. As a consequence, the EV limit is characterized by hierarchical contacts whereby the distribution of distances between near-neighbor residues is narrow and peaked around smaller values
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. An important time window in the picosecond-to-nanosecond time range is occupied by atomic thermal fluctuations, which have been extensively investigated by molecular dynamics (MD) simulations (2), and by various experimental approaches including neutron scattering (3,4) and nuclear magnetic resonance (NMR) (5)
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. Both lyophilized powders were placed in aluminum sample holders (30 × 40 × 0
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. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
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. Autoregressive errors of this sort render the standard OLS covariance matrix estimator inconsistent
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. However, as indicated by the z-test, the magnitude of the correlation coefficients between the SLSI and the MCS-12 did not vary significantly across the three respective class years
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. The discovery and characterization of partially folded states known as molten globules (MG) were important to our understanding of protein folding mechanisms (Dolgikh et al
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. The concentration of ANS, as determined by absorbance at 370 nm, using ε^sub 370^ = 6800 M^sup -1^Cm^sup -1^ (in methanol), ranged between 10 and 450 µM although in most experiments the upper limit was 320 µM
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. NMR study of Brownian tumbling and internal motions in proteins
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. The C^sub p^(T) data of intact disks shows two peaks (Fig
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.Following pasteurization, it is important to cool the mix to 40[degrees]F or lower
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. 4 D), on the other hand, a smooth continuation at 8 ns of the configurational entropy buildup is observed when the complex trajectory is appended to the free one (solid line), whereas a slight stepwise increase is visible when the trajectories are appended in the reverse order (dashed line)
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