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In this work we describe the characteristics of prefibrillar and protofibrillar assemblies of TTR and present a platform for spectroscopic characterization of these species
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In addition, our previous MD analysis of the intermolecular hydrogen bonding shows that all these residues, except CD4-K22, form only marginally stable intermolecular hydrogen bonds
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Because this peak does not provide relevant FRET (distance) information, only the region above E = 0
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The intensity of positive immunostaining was generally moderate but was not graded
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