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. Then, one is tempted to ask, is there any relationship among the different functions and structures of the PTS proteins on one side, and the thennodynamic parameters and folding properties on the other? To answer this question, it is necessary to describe the conformational preferences of proteins, where studies of different members of the family have been described
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. The fluorescence emission of the folded state is already rather blue shifted (λ^sub max^ = 327 nm), but also rather large λ^sub max^-values (341-344 nm) for the unfolded states contribute significantly to the large red shift
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. The V4 loop (residues 398-409), for which electron density is missing in all crystal structures, and the V3 loop, which has been proposed to undergo significant rearrangements upon CD4 binding, were modeled onto the gp120 core, together with the six core mutations of the LAI strain (98
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