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Overall, drug companies accounted for 15 percent of the firm's lobbying income
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Transient association of newly synthesized unfolded proteins with the heat-shock GroEL protein
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Hence, not many orientations of the glycan chain upon attachment to the protein are possible and we assume that upon energy minimization, the structure obtained mimics the real situation
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the development of a robust understanding of preferential interactions in cosolute mixtures (31-36)
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This feature can either by related to arising tyrosine emission (often observed around 305 nm for unfolded states when energy transfer to tryptophans disappears during a structural expansion of the protein; see, for example, Schmid (20)) or to elastic scattering caused by aggregation
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1 A shows the ^sup 1^H MR image of a single cell, a stage VI X
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The C-terminal hydrophobic peptide was deleted by insertion of a stop codon to obtain a soluble protein, and the loop 103-136 was replaced by three histidines to facilitate purification
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Proteins: a theoretical perspective of dynamics, structure, and thermodynamics
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Consequently, the high-temperature DSC transition involves apoA-2 unfolding
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In large posttransition juveniles ([greather or equal to] 47 mm BL), the membrane of the dorsal fin was pigmented more densely between the spines than between the rays; there were also dark blotches on the membrahe between the rays
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For additional information about the CDRF and the research it supports, visit www
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., and Javier Casanova for excellent technical assistance
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. Although the fluorescence intensity signal exhibits this proportionality to the population of the microstates (i
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. A possible explanation for this large red shift during thermal unfolding, which is almost as large as those obtained with GndHCl-induced unfolding (see Table 2), may be given by the fact that the absent aggregation gives rise to only a weak burial of tryptophan residues
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. Structural dynamics of liganded myoglobin
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. The brief high temperature treatment of insulin results in a marked broadening of the height-distribution of the particles and its shift toward larger oligomers, which is shown in Fig
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. These include, but are not restricted to, native and near-native hydrophobic side-chain interactions
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