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Unlike Catholic churches where bishops and cardinals have the final say, the semi-independent status of mainline congregations allows them to play the market more freely
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, announced the closing of $2
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The stability of GR dimers is also largely generated by the interface domain, since double or even single mutations in this region are sufficient to lead to the assembly of less stable dimers in the E
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Van der Broeck, M
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In the modeled structure, there was a long α-helix that is supposed to serve as a linker to the EIC domain
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Folding and stability of El^sup sc^ in the absence of effectors Two unfolding mechanisms have been described in oligomeric proteins exposed to high temperatures or high concentrations of chemical denaturants at equilibrium (49-51): 1), dissociation followed by unfolding of the native or partially unfolded monomeric species; and 2), denaturation without the accumulation of the native dissociated species
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This work was supported by an Atorvastatin Research Award (R
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However, at least on a qualitative level in particular differences between several unfolded states can be detected easily
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This investigation aims to complement that initial study by addressing the following issues: i), establish whether the perturbation of protein structure reported for azurin is general to other proteins; ii), inquire on potential correlations between the susceptibility to the ice-induced perturbation and specific features of the macromolecule such as thermodynamic stability, internal flexibility, internal cavities/hydration, and covalent links between strands; and finally iii), test for a specific vulnerability of multimeric proteins to freeze damage that may be linked to the disruption of quaternary structure
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In the case of NC flux shown in Fig
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Two of the hinge regions are formed by the flexible part of the central helix of the CaM molecules, and the other two hinge regions are formed by the flexible dimerization interfaces
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At pHs in the vicinity of the isoelectric point (pH 5
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Diffusional barrier crossing in a two-state protein folding reaction
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Despite the limited sampling time of 10 ns, the theoretically derived changes in configurational entropy are in fair agreement with the experimentally determined data
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Continuous cultures of fused cells secreting antibody of predefined specificity
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com still generates the bulk of its sales, between 55 percent and 60 percent in pharmacy
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This latter policy was responsible for about $0
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Cuthbert worries about vultures that dine where conservationists in Africa set out dead livestock
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But this year the phrase may take on new meaning, not only because of this daunting list of challenges facing retail pharmacy, but because according to the Chinese calendar it's the Year of the Dog
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More than any single event in modern history, it showcased not only pharmacy's willingness to put professional considerations and the health needs of patients ahead of profits, but also the industry's ability to respond to disaster more rapidly and more effectively than any federal agency in the early days
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