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The major bottleneck to overcome in the design of efficient Monte Carlo simulations is the O(N^sup 2^) complexity associated with computing energies for each new conformation gambling addiction canada .
The gyration tensor is computed as an outer product of the radius of gyration vector gambling addiction canada .
The accuracy of these ensembles is judged by matching the structural characteristics of the simulated ensembles to those predicted by field theories gambling addiction canada .
These hierarchical distance distributions reflect the so-called dilatation symmetry in the EV limit whereby contact density maps for one protein sequence can be rescaled to obtain the contact density map for another sequence gambling addiction canada .
For all sequence separations that go beyond ~7 residues, ensemble-averaged internal distances show the same power law behavior as R^sub g^ and R^sub e^ gambling addiction canada .
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Transmission electron microscopyFive microliter aliquots from a TTR misfolding reaction were withdrawn at different time points and were placed on a carbon coated copper grid for 2 min gambling addiction canada .
Protein association to membranes is stabilized by a combination of electrostatics as well as polar and hydrocarbon interactions gambling addiction canada .
Moreover, since subtle structural differences are thought to underlie the puzzling phenomenon of prion strains (Peretz et al gambling addiction canada .
However, based on the observed FRET efficiency, the two loop-carrying arms appear to be relatively far apart in that species, approximately midway between the extended and docked conformers gambling addiction canada .
A 100 µl aliquot of both the samples and standards was pipetted into a 96 well plate gambling addiction canada .
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