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In the interview, ask: Have you ever worked in this kind of situation before? What is your personal strategy for getting work done remotely? Do you have a dedicated office space at home with the necessary technology? Finally, O'Neil says, "Listen to your gut
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Each of these methods comes with problems
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, nutrition advisor for the American Institute for Cancer Research (AICR) in Washington, D
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4 µM) was dissolved in 0
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Protein measurement with the folin phenol reagent
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In their original work, Plaxco et al
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These results would make sense if denatured-state topologies were equivalent and invariant with sequence
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We have previously characterized the binding of PLCβ^sub 1-3^ enzymes to different model membranes and found that they bind strongly to various membranes with little specificity (Runnels et al
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Protein unfolding was triggered by an increase in guanidinium hydrochloride (Gdm HCl) concentration from 0 M to 1-6 M
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Energetics of hydrogen bond networks in RNA: Hydrogen bonds surrounding G+1 and U42 are the major determinants for the tertiary structure stability of the hairpin ribozyme
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Tertiary structure formation in the hairpin ribozyme monitored by fluorescence resonance energy transfer
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In this collection of 11 articles, contributors describe their work in PTKs in such areas as using PTKs as targets for cancer and other indications, targeting Src homology 2 domains in drug discovery, using P12-kinase inhibition as a target for therapeutic intervention, using an activated FLT3 receptor tyrosine kinase as a therapeutic target in leukemia and JAK kinases in leukemia, lymphomas and multiple myeloma, applying platelet-derived growth factor, using a targeted therapy for myelogenous leukemia, testing signal transduction inhibitors in animal models of cancer, and using phosphoproteomics in drug discovery and development
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Poston had already helped Malvika corroborate her alibi and get her charges dropped, and eventually he was able to do the same for Siddharth--but not before the hapless defendant had to spend $55,000 in legal fees and endure twelve days of incarceration
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This result is consistent with the findings of Damush et al
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. (40)ProliferationThe maintenance of alveolar integrity may be critically dependent on intact efferocytosis mechanisms, because it results in the release of growth factors and the activation of signaling molecules involved with the maintenance of the epithelium and endothelimn (Fig 3)
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. ^sup 15^N-{^sup 1^H} NOE values were determined from the ratios of peak volumes recorded in presence and absence of proton saturation
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. Therefore, a purely diffusion-controlled on-rate k^sub on^ of 10 s^sup -1^ M^sup -1^ would put a lower limit on the CaM:SEF2-1mp affinity, k^sub off^/k^sub on^ > 10^sup -6^
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. Protein association to membranes is stabilized by a combination of electrostatics as well as polar and hydrocarbon interactions
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. 5), the entropy buildup curves show a substantial jump at the appending point when the trajectory of the free form is appended to that of the complex form (dashed line), indicating that the free molecule samples conformational space not visited in the complex simulation (case A; Fig
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