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. People with sickle cells often suffer chronic anemia, extreme pain, and organ damage
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. This fold comprises a six-stranded hack β-sheet, a curved seven-stranded trout β-sheet and a rive-stranded sheet that forms the roof of the molecule (14,15)
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. This is evident in the more rapid deeay of P(x) for large x in the EV limit
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. Analysis of a ptsH homologue from Streptomyces coelicolor A3(2)
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. Subsequently, the ice was melted, leaving a small ice seed that was used for controlled freezing in a bath at -10°C
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. Ice-induced ANS binding to other proteins To examine whether the ice-induced perturbation observed for azurin is common to proteins in general, ANS binding experiments were extended to a set of seven other proteins including monomeric BSA, α-amylase and β-gal, dimeric LADH and tetrameric ALD, YADH, and LDH
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. Macromolecular binding, however, prevents an exact quantification of the drug concentration-especially at or near the lower detection limit-in the different cellular compartments, which would be required for a detailed kinetic analysis of drug uptake
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. The wettability of Sn-2
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. 5 ns with S^sup 2^^sub s^ of ~0
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. Higher pressures (usually above 5 kbars) will result in penetration of solvent into the protein matrix, resulting in a molten globule (e
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. DISCUSSION AND CONCLUSIONSWe have discussed a conceptual approach to the protein landscape problem that attempts to remain faithful to the high dimensionality of the system
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. In the combined trajectory analysis (Fig
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. We studied the effect of dissolving temperature and Isopar type (G, H, and L) on the average particle size
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