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. RESULTS In this work, we focus on two-state proteins because the hypothesis is that only two well-defined macrostates-native and highly denatured states-are accessible to these systems (67-70)
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. Although less confined than CD4-F43, it is in close contact (In addition to the residues that are directly involved in intermolecular contacts or are in close proximity to the intermolecular interface, there are a few residues in gp120 that show large intraresidue entropy changes upon complexation (see Fig
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