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This two-stage scheme is similar to that from the chemical unfolding/ refolding studies of ACYI (18,19), which also indicated that there existed a dimeric, aggregation-prone folding intermediate
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As a consequence, several special characteristics of conformational ensembles for polymers in the EV limit-and, by extension, of highly denatured proteins-are not anticipated by Flory's theory
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Deantured slates of proteins
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To perform studies in this direction the conformational stability of encapsulating structures at rather elevated temperatures (above 80°C) needs to be ensured
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On the contrary, an important consequence of creating an internal cavity of 40 in I7S and 100 [Angstrom]^sup 3^ in F110S, presumably filled with water (18,19), is the onset of large amplitude structural fluctuations that increase remarkably the flexibility of the globular fold, as evidenced by the three to four orders of magnitude increase in permeability to acrylamide (18)
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Large-scale purification and long-term stability of human butyrylcholinesterase: a potential bioscavenger drug
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Such scan rate dependence, which was also observed in apoA-1:DMPC (Surewicz et al
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, Formation of Polypropylene Particles via Thermally Induced Phase Separation, Polymer 41 (24), 86738679 (2000)
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As a result, the antibodies were reactive with all the P
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For the time being, access to these lifesaving drugs depends on the tiny percentage of the population legally empowered to dole them out
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We focused on seniors given that they are the highest per capita users of analgesics (Health Canada 2003), and the size and composition of the beneficiary population is relatively stable over time
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We could not reject these hypotheses at the ,5 percent level (Table l)
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It was clear that the time had come for further changes
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This includes data on body fluid concentrations of substances in normal or therapeutic situations, concentrations in fluids and tissues in instances of toxicity, toxic effects, chemical structures, and brief discussion of analytic procedures for the determination of substances in biological specimens
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