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. © 2007 by the Biophysical Society 0006-3495/07/01/578/10 $2
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. 4, s^sub i^ = (r^sub i^ - r^sub CM^), where r^sub CM^ is the position vector of the center of mass and r^sub i^ denotes the position vector of the α-carbon for residue i
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. Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations
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. Although for BSA a high binding capacity may be expected from its intrinsic tendency to bind nonpolar and aromatic moieties also in the liquid state, the above ANS binding data do suggest that beyond specific trends of individual polypeptides, multi-subunit proteins are more susceptible than monomers to destabilization and partial unfolding in the frozen state
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. RESULTSThe compaction of giant T4 DNA in PEG-salt systems was monitored by fluorescent microscopy at the level of single DNA chains
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. The range of accessible quaternary fibrillar folds is not yet limited to these structural motifs, as the study on apolipoprotein C-II, which forms closed rings of amyloid (Hatters et al
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. 6), and applied (30 µL) onto freshlycleaved muscovite mica (9 mm diameter) attached to a 15-mm magnetic steel disc (serving as sample holder)
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. Consideration of both typical range of stabilizing interactions, and folding rates themselves, leads to a model of the energy hypersurface that is characterized by the structure of diffusive "hypergutters" as well as the familiar "funnels"
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. Most of these compounds are associated with the milk fat globule membrane (MFGM)
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