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and 1 1 did not yield a sigmoidal behavior (data not shown)
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For example, early studies (64) of anti-TNF therapy in patients with mild asthma did not improve outcomes, whereas later studies (65) in refractory asthma suggest a role for this approach
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We thank Janny Hof for critical reading of the manuscript
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Atmospheric measurements were performed using 3-mm cuvettes
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The unfolding was triggered at t = 0 by a temperature-jump from 25°C to 75-95°C and was monitored by CD at 222 nm (Fig
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Apart from the faster kinetics, the increased temperature of 70°C leads to a higher degree of morphological variability: along straight rods, twisted ribbonlike structures, rod bundles, and ropelike structures become prominent in the corresponding AFM data
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METHODSThree simulations of 10 ns at 300 K, 1 atm, were carried out for three different systems in explicit solvent: free HIV-1 gp120 with the truncated LAI strain sequence (SWISS-PROT accession number P03377; 346 residues and 29,047 water molecules), free CD4 (99 residues of the D1 domain and 7768 water molecules), and their complex (445 residues and 30,242 water molecules)
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[12] prepared polypropylene particles by means of TIPS
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