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Both the Flory random-coil model and field theories agree that all sequence-specific biases are strictly local and that denatured-state ensembles show significant conformational heterogeneity
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All fluorescence spectra were corrected for background scattering as measured with pure buffer
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1 ) reach a more buried and nonpolar microenvironment in the unfolded state
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The inhibited enzyme has a denaturation midpoint temperature in D^sub 2^O-solution which is shifted by 10°C from 337
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Is random close packing of spheres well defined? Phys
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Fluorescent probes for polymer free-volume
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The second DSC peak is centered at 84°C, which is similar to the apparent T^sub m^ determined from the peak position in the first derivative of the CD melting data, dΘ^sub 222^(T)/dT (Fig
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Probing the mechanism of insulin fibril formation with insulin mutants
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Despite its high occurrence (78%), the salt bridge between CD4-K22(Nζ) and gp120-E429(Cδ) located at the edge of the interface of the molecular complex might be subject to fewer structural limitations than those in the center of the interface
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1994, Dexter 1978, Hayward et al
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