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. Structural rearrangements then take place at the dimer interface (and presumably also in other domains of each subunit), leading to a final, compact dimer structure
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. In newborn kittens, for instance, neurons of the visual cortex are activated and connected to both eyes
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. How the dilatation symmetry of denatured states is broken under folding conditions will depend on a variety of factors including local biases for turns and short stretches of extended or helical conformations, the drive to sequester hydrophohic amino acids, and the achievement of specificity in side-chain packing (103)
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. At the other end of the spectrum, recent experimental work and some modeling efforts suggest that a new paradigm is in order for denatured-state ensembles (100,101,130)
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. But MRS voxels can currently not be that small because the ^sup 1^H signal from nonwater metabolites naturally is very low and because a reduction in MRS voxel size brings about increasing eddy currents that effectively block the MR signal recording
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. FRET histograms were fit with multiple Gaussian functions using Origin (OriginLab Corp
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. The corresponding conformational entropy differences with their respective standard error estimates from the block averaging analysis are summarized in Table 2
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