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. "These pills raise your blood pressure and heart rate," says study author Christopher Gange, M
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. There was no clear difference between N and A states in contrast to the 25% reduction of helix content and the 50% reduction of heat capacity change upon unfolding
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. HPRI-CT-2001-50035 and RII3-CT-2003-505925
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. INTRODUCTIONCalmodulin (CaM) is a Ca^sup 2+^ binding protein, present in all eukaryotic cells
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. As described in the Theory section, k^sub ex^ can be derived from the correlation between R^sub ex^ and ΔR^sub ex^ without prior assumption on the timescale of the exchange
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. It was shown in a seminal article by Semisotnov and co-workers that a blue shifted ANS fluorescence spectrum and a strongly increased quantum yield is diagnostic of binding to a molten-globule-like state with exposed hydrophobic patches (Semisotnov et al
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. We treated Gα^sub s^(GDP) with dithiothreitol (see Philip and Scarlata, 2004) and found that its pressure behavior was unchanged (data not shown)
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